Sulfamethoxazole and trimethoprim are are both antibiotics that treat different types of infection caused by bacteria
Although other combinations of sulfonamides are available with trimethoprim, TMP-SMX is by far the most widely used
[2] [7] It is used both to treat and prevent pneumocystis pneumonia and toxoplasmosis in people with HIV/AIDS and other causes of immunosuppression
They're a type of oral antibiotic
Also tell them if you smoke Trimethoprim: Uses, Interactions, Mechanism of Action | DrugBank Online Trimethoprim is often given in combination with sulfamethoxazole, which inhibits the preceding step in bacterial protein synthesis - given together, sulfamethoxazole and trimethoprim inhibit two consecutive steps in the biosynthesis of bacterial nucleic acids and proteins
Without insurance, generic Bactrim is typically a low-cost drug, defined in this article as costing less than $30/month
BACTRIM (sulfamethoxazole and trimethoprim) is a synthetic antibacterial combination product available in DS (double strength) tablets, each containing 800 mg sulfamethoxazole and 160 mg trimethoprim; in tablets, each containing 400 mg sulfamethoxazole and 80 mg trimethoprim for oral administration
The usual application timetable involves taking this drug from 2 to 4 times daily, depending on the type of condition you have and exactly how intense it is Bactrim (sulfamethoxazole and trimethoprim) is a combination drug made use of for the procedure of a variety of infections created by germs
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There are 335 drugs known to interact with sulfamethoxazole, along with 9 disease interactions, and 1 alcohol/food interaction
[1] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS
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Shigellosis, ≥2 months of age: Injection: 8-10 mg/kg/day (based on the trimethoprim component) given in equally divided doses every 6, 8, or 12 hours for up to 5 days
The original antibacterial sulfonamides are Beta-lactam antibiotics are used in the management and treatment of bacterial infections
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unsteadiness, trembling, or other problems with muscle control or coordination
The term "bacteriostatic antibiotics" is used to describe medications whose mechanism of action stalls bacterial cellular activity without directly causing bacterial death
Maximum dose: 960 mg/day (trimethoprim component) Oral: Sulfamethoxazole-trimethoprim 800 mg-160 mg orally every 12 hours for 5 days
26 terms
Data sources include Micromedex (updated 4 Feb 2024), Cerner Multum™ (updated 4 Feb 2024), ASHP (updated 12 Feb 2024) and others
Mechanism Of Action
Antibiotics that should be reserved for treatment of confirmed or suspected infections with multi-drug resistant organisms
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The dose of TMP-SMX for patients with normal renal function is 15 to 20 mg/kg (dosing is based upon the TMP component and expressed as mg/kg per day of TMP The sulfamethoxazole component belongs to the class of medicines known as sulfonamides, and the trimethoprim component belongs to the class of medicines known as folic acid inhibitors
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Trimethoprim is a synthetic antibacterial available in tablet form for oral administration
For a complete list of side effects, please refer to the individual drug monographs
An increased risk of congenital malformations (neural tube defects, cardiovascular malformations, urinary tract defects, oral clefts, club foot) following maternal use of sulfamethoxazole and trimethoprim during pregnancy has been observed in some studies
Class
Trimethoprim is metabolized in vitro to 11 different metabolites, of which, five are glutathione adducts and six are oxidative metabolites, including the major metabolites, 1- and 3-oxides and the The recommended dosage for prophylaxis in adults is 1 BACTRIM DS (double strength) tablet daily
There is some evidence that substances present in soy may stimulate breast tumor growth and interfere with the action of tamoxifen, although this has not been proven
Flagyl may cause serious side effects including: diarrhea, painful or difficulty urinating, Trimethoprim comes as a tablet to take by mouth
N4-hydroxylation of sulfamethoxazole by cytochorme P450 of the cytochorme P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes
This type of drug is another antifungal compound whose mechanism of action is the loss of cell membrane integrity
See more Trimethoprim/sulfamethoxazole, also known as co-trimoxazole and can be abbreviated in the following ways: SXT, TMP
Uses
Drugs & Medications
Side Effects
Sulfamethoxazole and trimethoprim is a combination antibiotic used to treat ear infections, urinary tract infections, bronchitis, traveler's diarrhea, shigellosis, and
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Sulfamethoxazole and trimethoprim is a drug combination prescribed for urinary tract infections (UTIs), middle ear infections, respiratory infections, pneumonia, chancroid, for the prevention of infections of transplant recipients, and prevention of toxoplasma encephalitis in patients with AIDS
Side Effects
The mechanisms of action of these antimicrobials are broad, and they generally require patients' to have functional immune systems to function optimally
However, warfarin falls in the narrow therapeutic index drug category and is subject to numerous interactions
trimethoprim decreases effects of BCG vaccine live by pharmacodynamic antagonism
hematologic toxicity
Upsides
It is completely absorbed following oral administration and has a half-life of about 10 hours
The drugs act
Beta-lactam antibiotics are used in the management and treatment of bacterial infections
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of sulfamethoxazole and trimethoprim combination in children 2 months of age and older
This is not a complete list of side effects and others may occur
difficile-related) diarrhea: rapid heart rate, foul-smelling diarrhea, fever, nausea, frequent bowel movements (even up to 15 times per day)Kidney problems: urinating less often than usual, swelling in
CrCl
Trimethoprim has recently been marketed as a single-entity product for the treatment of initial episodes of uncomplicated symptomatic urinary tract infections; it was previously available only in combination with sulfamethoxazole