The selective α1-adrenergic antagonist prazosin has been shown in multiple studies to be effective in targeting trauma-related nightmares in posttraumatic stress disorder
Prazosin blocks norepinephrine, a stress hormone that affects your brain, at specialized chemical receptors called alpha-1 receptors
Management
Only one
Prazosin, a selective alpha-1 adrenergic antagonist, has been suggested to treat nightmares, with
Prazosin is a well-tolerated generically available medication that has a small but positive evidence base for the treatment of PTSD-associated nightmares
1
Prazosin may be used to treat both PTSD-associated and idiopathic nightmare disorder
Medically reviewed by
Prazosin for Nightmares User Reviews
It is an α 1 blocker
Treatment of Nightmares with Prazosin: A Systematic Review Journal of Clinical Sleep Medicine is a peer-reviewed journal that publishes original research and reviews on various aspects of sleep disorders and their treatment
The dose is then gradually increased to maintenance levels of 2-6 mg at night
Posttreatment decreases in the mean weekly nightmare frequency, as measured by sleep diary, were greater for the prazosin group than for the placebo group (pretreatment: prazosin 1
Background: Prazosin has been an accepted treatment for patients with post-traumatic stress disorder (PTSD) who experience sleep disturbances, including nightmares
Prazosin may also block nerve receptors responsible for contracting (narrowing) blood vessels
Background: The aim of this systematic review was to identify published articles that evaluated the use of prazosin for treating nightmares in children and adolescents who have posttraumatic stress disorder (PTSD)
Trial Regimen and Other Treatments
Prazosin is an alpha-adrenergic antagonist with a two to three hour half-life
At the VA, olanzapine resolved nightmares in one case (5
Prazosin, a selective alpha-1 adrenergic antagonist, has been suggested to treat nightmares, with most data supporting its use in post-traumatic stress disorder (PTSD)
This helps to lower blood pressure
The nightmares caused severe sleep disturbances resulting in psychological stress
A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder Biol and coping strategies are intended to help deal with the nightmares
For global symptoms of PTSD, there is a suggestion against the use of prazosin
While clonidine is used clinically for the treatment of nightmares in posttraumatic stress disorder (PTSD), few case reports demonstrating this indication exist, and there have been few studies investigating clonidine's mechanism of action for controlling nightmare symptoms